Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neuron, Cell Culture
DISEASE(S): Frontotemporal Dementia
SUBMITTER: Eric Fischer
LAB HEAD: Eric Fischer
PROVIDER: PXD012515 | Pride | 2019-03-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
esf_1936.raw | Raw | |||
esf_1937.raw | Raw | |||
esf_1938.raw | Raw | |||
esf_1939.raw | Raw | |||
esf_1940.raw | Raw |
Items per page: 1 - 5 of 25 |
eLife 20190325
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas. Positron emission tomography (PET) tracers that bind to pathological tau are used in diagnosis, but there are no current therapies to eliminate these tau species. We employed targeted protein degradation technology to convert a tau PET-probe into a functional degrader of pathogenic tau. The hetero-bifunctional molecule QC-01-175 was designed to en ...[more]