Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Joern Dengjel
LAB HEAD: Joern Dengjel
PROVIDER: PXD012612 | Pride | 2022-04-27
REPOSITORIES: Pride
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Ring Julia J Tadic Jelena J Ristic Selena S Poglitsch Michael M Bergmann Martina M Radic Nemanja N Mossmann Dirk D Liang YongTian Y Maglione Marta M Jerkovic Andrea A Hajiraissi Roozbeh R Hanke Marcel M Küttner Victoria V Wolinski Heimo H Zimmermann Andreas A Domuz Trifunović Lana L Mikolasch Leonie L Moretti Daiana N DN Broeskamp Filomena F Westermayer Julia J Abraham Claudia C Schauer Simon S Dammbrueck Christopher C Hofer Sebastian J SJ Abdellatif Mahmoud M Grundmeier Guido G Kroemer Guido G Braun Ralf J RJ Hansen Niklas N Sommer Cornelia C Ninkovic Mirjana M Seba Sandra S Rockenfeller Patrick P Vögtle Friederike-Nora FN Dengjel Jörn J Meisinger Chris C Keller Adrian A Sigrist Stephan J SJ Eisenberg Tobias T Madeo Frank F
EMBO molecular medicine 20220404 5
Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer's disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast model to study aspects of intracellular Abeta42 toxicity, we here identify the HSP40 family member Ydj1, the yeast orthologue of human DnaJA1, as a crucial factor in Abeta42-mediated cell death. We demonstrate that Ydj1/DnaJA1 physically interacts with Abeta42 ( ...[more]