Changes in S-nitroslyaion in a mouse model of preeclampsia
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Placenta
DISEASE(S): Pre-eclampsia
SUBMITTER: 
Niveda Sundararaman
LAB HEAD: Jennifer Van Eyk
PROVIDER: PXD012706 | Pride | 2022-05-19
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 18_11_9_Mouse_UNIPROT_DECOY.fasta | Fasta | |||
| CM_180728_LUMOS_10H.mzXML | Mzxml | |||
| CM_180728_LUMOS_10H.raw | Raw | |||
| CM_180728_LUMOS_11H.mzXML | Mzxml | |||
| CM_180728_LUMOS_11H.raw | Raw |
Items per page: 5 1 - 5 of 80 |
Publications
S-Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S-Nitrosylation and Preeclampsia.
Kulandavelu Shathiyah S Dulce Raul A RA Murray Christopher I CI Bellio Michael A MA Fritsch Julia J Kanashiro-Takeuchi Rosemeire R Arora Himanshu H Paulino Ellena E Soetkamp Daniel D Balkan Wayne W Van Eyk Jenny E JE Hare Joshua M JM
Journal of the American Heart Association 20220222 5
Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S-nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation and nitrosative stress. Methods and Results Here, we show that mice lacking S-nitrosoglutathione reductase (<i>GSNOR<sup>-⁄-</sup></i>), a denitrosylase regulating protein S-nitrosylation, exhibit a preeclampsia phenotype, including hypertension, protein ...[more]
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