Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE126990
INSTRUMENT(S): LTQ Orbitrap, Q TRAP
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Gerhard Dürnberger
LAB HEAD: Jan-Michael Peters
PROVIDER: PXD012712 | Pride | 2019-11-13
REPOSITORIES: Pride
Items per page: 1 - 5 of 144 |
eLife 20190617
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating cells, cohesin also mediates sister chromatid cohesion, which is essential for chromosome segregation. Current models of chromatin folding and cohesion are based on assumptions of how many cohesin and CTCF molecules organise the genome. Here we have me ...[more]