Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, T Cell
DISEASE(S): Melanoma
SUBMITTER: John Koomen
LAB HEAD: Sungjune Kim, MD
PROVIDER: PXD012796 | Pride | 2020-06-15
REPOSITORIES: Pride
Hamaidi Imene I Zhang Lin L Kim Nayoung N Wang Min-Hsuan MH Iclozan Cristina C Fang Bin B Liu Min M Koomen John M JM Berglund Anders E AE Yoder Sean J SJ Yao Jiqiang J Engelman Robert W RW Creelan Ben C BC Conejo-Garcia Jose R JR Antonia Scott J SJ Mulé James J JJ Kim Sungjune S
Cell metabolism 20200807 3
Dysregulated metabolism is a key driver of maladaptive tumor-reactive T lymphocytes within the tumor microenvironment. Actionable targets that rescue the effector activity of antitumor T cells remain elusive. Here, we report that the Sirtuin-2 (Sirt2) NAD<sup>+</sup>-dependent deacetylase inhibits T cell metabolism and impairs T cell effector functions. Remarkably, upregulation of Sirt2 in human tumor-infiltrating lymphocytes (TILs) negatively correlates with response to TIL therapy in advanced ...[more]