Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Yang Liu
LAB HEAD: Arthur Laganowsky
PROVIDER: PXD012894 | Pride | 2019-04-02
REPOSITORIES: pride
Action | DRS | |||
---|---|---|---|---|
01302019_art_folded.msf | Msf | |||
01302019_art_folded.raw | Raw |
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Nature communications 20190322 1
G-protein-gated inward rectifying potassium channels (GIRKs) require G<sub>βγ</sub> subunits and phosphorylated phosphatidylinositides (PIPs) for gating. Although studies have provided insight into these interactions, the mechanism of how these events are modulated by G<sub>βγ</sub> and the binding affinity between PIPs and GIRKs remains poorly understood. Here, native ion mobility mass spectrometry is employed to directly monitor small molecule binding events to mouse GIRK2. GIRK2 binds the tox ...[more]