Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Multipotent Stem Cell, Bone Marrow
SUBMITTER: Venkatesh Mallikarjun
LAB HEAD: Joe Swift
PROVIDER: PXD012948 | Pride | 2019-04-24
REPOSITORIES: Pride
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Nature communications 20190912 1
Studies of cellular mechano-signaling have often utilized static models that do not fully replicate the dynamics of living tissues. Here, we examine the time-dependent response of primary human mesenchymal stem cells (hMSCs) to cyclic tensile strain (CTS). At low-intensity strain (1 h, 4% CTS at 1 Hz), cell characteristics mimic responses to increased substrate stiffness. As the strain regime is intensified (frequency increased to 5 Hz), we characterize rapid establishment of a broad, structured ...[more]