Dataset Information

Dasatinib for the treatment of gastric cancer

ABSTRACT: Gastric cancer (GC) represents a major health problem, remaining the fifth most common type of cancer and the third leading cause of cancer-related death worldwide with only few targeted therapies available to date. The positive effect of kinase inhibitors on many different types of cancers has prompted the investigation of these compounds also in GC. In a screen of FDA-approved kinase inhibitors, dasatinib was found as a potent inhibitor of gastric cancer cells migration and invasion. In order to identify the kinases involved proteomics analysis was performed identifying SRC kinases, Ephrins and DDR1 as potential molecular targets.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Stephanie Wilhelm

LAB HEAD: Bernhard Kuster

PROVIDER: PXD012953 | Pride | 2020-05-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	01411_A08_P014174_B00_A00_R1.raw	Raw
	01411_A09_P014182_B00_A00_R1.raw	Raw
	01411_B08_P014175_B00_A00_R1.raw	Raw
	01411_B09_P014183_B00_A00_R1.raw	Raw
	01411_C07_P014168_B00_A00_R1.raw	Raw

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Publications

Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib.

Montenegro Raquel Carvalho RC Howarth Alison A Ceroni Alessandro A Fedele Vita V Farran Batoul B Mesquita Felipe Pantoja FP Frejno Martin M Berger Benedict-Tilman BT Heinzlmeir Stephanie S Sailem Heba Z HZ Tesch Roberta R Ebner Daniel D Knapp Stefan S Burbano Rommel R Kuster Bernhard B Müller Susanne S

Oncotarget 20200204 5

Gastric cancer (GC) remains the third leading cause of cancer-related death despite several improvements in targeted therapy. There is therefore an urgent need to investigate new treatment strategies, including the identification of novel biomarkers for patient stratification. In this study, we evaluated the effect of FDA-approved kinase inhibitors on GC. Through a combination of cell growth, migration and invasion assays, we identified dasatinib as an efficient inhibitor of GC proliferation. Ma ...[more]

PMID: 32082487

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