Proteomics

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Role of ppiB in burkholderia pseudomallei

ABSTRACT: Burkholderia pseudomallei is the causative agent of melioidosis a disease endemic in South-East Asia and Northern Australia. The mortality rates in these areas are unacceptably high even with antibiotic treatment, attributed to intrinsic and acquired resistance of B. pseudomallei to antibiotics. With very few options for therapeutics there is an urgent requirement to identify anti-bacterial targets for the development of novel, effective treatments. In this study we examine the role and effect of ppiB on the proteome. Using LFQ analysis we show loss of ppiB has dramatic effect on the Burkholderia pseudomallei proteome.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Burkholderia Pseudomallei

SUBMITTER: Nichollas Scott  

LAB HEAD: Dr Mitali Sarkar-Tyson

PROVIDER: PXD012956 | Pride | 2019-08-05

REPOSITORIES: Pride

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Publications

Peptidyl-Prolyl Isomerase <i>ppiB</i> Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei.

Bzdyl Nicole M NM   Scott Nichollas E NE   Norville Isobel H IH   Scott Andrew E AE   Atkins Timothy T   Pang Stanley S   Sarovich Derek S DS   Coombs Geoffrey G   Inglis Timothy J J TJJ   Kahler Charlene M CM   Sarkar-Tyson Mitali M  

Infection and immunity 20190919 10

<i>Burkholderia pseudomallei</i> is the causative agent of melioidosis, a disease endemic to Southeast Asia and northern Australia. Mortality rates in these areas are high even with antimicrobial treatment, and there are few options for effective therapy. Therefore, there is a need to identify antibacterial targets for the development of novel treatments. Cyclophilins are a family of highly conserved enzymes important in multiple cellular processes. Cyclophilins catalyze the <i>cis-trans</i> iso  ...[more]

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