Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, SYNAPT G2-Si, Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Andy Lau
LAB HEAD: Argyris Politis
PROVIDER: PXD013018 | Pride | 2019-09-13
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 59 |
Faull Sarah V SV Lau Andy M C AMC Martens Chloe C Ahdash Zainab Z Hansen Kjetil K Yebenes Hugo H Schmidt Carla C Beuron Fabienne F Cronin Nora B NB Morris Edward P EP Politis Argyris A
Nature communications 20190823 1
Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated Cullins. Here we present structures of the neddylated and deneddylated CSN-CRL2 complexes by combining single-particle cryo-electron microscopy (cryo-EM) with chemical cross-linking mass spectrometry (XL-MS). These structures suggest a conserved mechanism of CSN activation, consisting of conformational clamping ...[more]