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DMD Biomarkers in 4 years boys, DMD vs. Control study

ABSTRACT: The aim of this project is to identify biomarkers in serum samples of very young DMD boys (4 years old)

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Duchenne Muscular Dystrophy

SUBMITTER: Tchilabalo ALAYI

LAB HEAD: Yetrib Hathout

PROVIDER: PXD013174 | Pride | 2021-01-30

REPOSITORIES: Pride

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			Action	DRS
	QE003213TA.mzML	Mzml
	QE003213TA.mzid.gz	Mzid
	QE003213TA.pride.mgf.gz	Mgf
	QE003213TA.raw	Raw
	QE003214TA.mzML	Mzml

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Publications

Tandem Mass Tag-Based Serum Proteome Profiling for Biomarker Discovery in Young Duchenne Muscular Dystrophy Boys.

Alayi Tchilabalo D TD Tawalbeh Shefa M SM Ogundele Michael M Smith Holly R HR Samsel Alison M AM Barbieri Marissa L ML Hathout Yetrib Y

ACS omega 20201006 41

Blood-accessible molecular biomarkers are becoming highly attractive tools to assess disease progression and response to therapies in Duchenne muscular dystrophy (DMD) especially in very young patients for whom other outcome measures remain subjective and challenging. In this study, we have standardized a highly specific and reproducible multiplexing mass spectrometry method using the tandem mass tag (TMT) strategy in combination with depletion of abundant proteins from serum and high-pH reverse ...[more]

PMID: 33110978

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