Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: ge mengkai
LAB HEAD: Guo-Qiang Chen
PROVIDER: PXD013196 | Pride | 2019-11-14
REPOSITORIES: Pride
Action | DRS | |||
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P_L_1.raw | Raw | |||
P_L_1.raw (F005032).mzid_P_L_1.raw_(F005032).pride.mgf.gz | Mzid | |||
P_L_1.rawF005032.mzid.gz | Mzid | |||
P_L_1.rawF005032.mzid_P_L_1.raw_F005032.MGF | Mzid | |||
P_L_10.raw | Raw |
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Nature cell biology 20191104 11
PTENα and PTENβ are two longer translational variants of phosphatase and tensin homolog (PTEN) messenger RNA. Their expressional regulations and functions in carcinogenesis remain largely unknown. Here, we demonstrate that, in contrast with the well-established tumour-suppressive role of canonical PTEN, PTENα and PTENβ promote tumourigenesis by directly interacting with the histone H3 lysine 4 (H3K4) presenter WDR5 to promote H3K4 trimethylation and maintain a tumour-promoting signature. We also ...[more]