Dataset Information

PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models

ABSTRACT: Understanding the precise molecular mechanisms behind chronic pain disorders such as migraine and opioid induced hyperalgesia (OIH) has been a long-standing goal met with limited success. Neuropeptides, which play a vital role in several physiological processes are also hypothesized to be involved in mediating these pain mechanisms. Here we show that change in levels of several neuropeptides and neuropeptide-precursor proteins (prohormones) correlate with migraine and OIH in mice. We also identified common prohormones that are significantly changed in both migraine and OIH. These results suggest that neuropeptides have an important role in these chronic pain disorders and might be key towards unlocking their mechanisms. This knowledge could eventually be utilized in developing an effective cure for these disorders.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Migraine

SUBMITTER: Krishna Anapindi

LAB HEAD: Jonathan V. Sweedler

PROVIDER: PXD013362 | Pride | 2019-11-06

REPOSITORIES: Pride

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PACAP and Other Neuropeptide Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models.

Anapindi Krishna D. B. KDB Yang Ning N Romanova Elena V EV Rubakhin Stanislav S SS Tipton Alycia A Dripps Isaac I Sheets Zoie Z Sweedler Jonathan V JV Pradhan Amynah A AA

Molecular & cellular proteomics : MCP 20191024 12

Chronic use of opioids can produce opioid-induced hyperalgesia (OIH), and when used to treat migraine, these drugs can result in increased pain and headache chronicity. We hypothesized that overlapping mechanisms between OIH and chronic migraine occur through neuropeptide dysregulation. Using label-free, non-biased liquid chromatography-mass spectrometry to identify and measure changes in more than 1500 neuropeptides under these two conditions, we observed only 16 neuropeptides that were altered ...[more]

PMID: 31649062

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			Action	DRS
	20151207_TG1.mgf	Mgf
	20151207_TG1.pride.mgf.gz	Mgf
	20151207_TG1.raw	Raw
	20151207_TG2.mgf	Mgf
	20151207_TG2.pride.mgf.gz	Mgf