Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q Exactive
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Heart, Cell Culture
SUBMITTER: Ilian Atanassov
LAB HEAD: Nils-Göran Larsson
PROVIDER: PXD013398 | Pride | 2019-04-25
REPOSITORIES: Pride
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EMBO reports 20190429 6
Regulation of replication and expression of mitochondrial DNA (mtDNA) is essential for cellular energy conversion via oxidative phosphorylation. The mitochondrial transcription elongation factor (TEFM) has been proposed to regulate the switch between transcription termination for replication primer formation and processive, near genome-length transcription for mtDNA gene expression. Here, we report that <i>Tefm</i> is essential for mouse embryogenesis and that levels of promoter-distal mitochond ...[more]