Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: Vytautas Iesmantavicius
LAB HEAD: Luca Giorgetti
PROVIDER: PXD013507 | Pride | 2019-06-03
REPOSITORIES: Pride
Redolfi Josef J Zhan Yinxiu Y Valdes-Quezada Christian C Kryzhanovska Mariya M Guerreiro Isabel I Iesmantavicius Vytautas V Pollex Tim T Grand Ralph S RS Mulugeta Eskeatnaf E Kind Jop J Tiana Guido G Smallwood Sebastien A SA de Laat Wouter W Giorgetti Luca L
Nature structural & molecular biology 20190527 6
Current understanding of chromosome folding is largely reliant on chromosome conformation capture (3C)-based experiments, where chromosomal interactions are detected as ligation products after chromatin crosslinking. To measure chromosome structure in vivo, quantitatively and without crosslinking and ligation, we implemented a modified version of DNA adenine methyltransferase identification (DamID) named DamC, which combines DNA methylation-based detection of chromosomal interactions with next-g ...[more]