Dataset Information

Analysis of protein abundance over the yeast respiratory oscillation at different dilution rates.

ABSTRACT: How does the abundance of different proteins change over the caurse of the yeast respirator oscillation and with nutrient availability (through changing dilution rate).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Sew Peak-Chew

LAB HEAD: John O'Neill

PROVIDER: PXD013653 | Pride | 2020-06-27

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	NH2363A_TMTphos_F1.msf	Msf
	NH2363A_TMTprot_F1.msf	Msf
	NH2363A_tmt_NoScNoNorm30_merge070717.pep.xml	Pepxml
	NH2363B_TMT_noScNoNorm30_030717.pep.xml	Pepxml
	NH2363B_TMTphos_F1-03.msf	Msf

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Publications

Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis.

O'Neill John S JS Hoyle Nathaniel P NP Robertson J Brian JB Edgar Rachel S RS Beale Andrew D AD Peak-Chew Sew Y SY Day Jason J Costa Ana S H ASH Frezza Christian C Causton Helen C HC

Nature communications 20200917 1

Yeast physiology is temporally regulated, this becomes apparent under nutrient-limited conditions and results in respiratory oscillations (YROs). YROs share features with circadian rhythms and interact with, but are independent of, the cell division cycle. Here, we show that YROs minimise energy expenditure by restricting protein synthesis until sufficient resources are stored, while maintaining osmotic homeostasis and protein quality control. Although nutrient supply is constant, cells sequeste ...[more]

PMID: 32943618

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