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The proteomics of EspC stimulated RAW264.7 cell lines

ABSTRACT: the proteomics of EspC stimulated RAW264.7 cell lines

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Macrophage

DISEASE(S): Tuberculosis

SUBMITTER: Qinglong Guo

LAB HEAD: Xuelian Zhang

PROVIDER: PXD013666 | Pride | 2021-09-08

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Lumos3_GQL.pep.xml	Pepxml
	Lumos3_GQL.prot.xml	Xml
	Lumos3_GQL_11_20170818.raw	Raw
	Lumos3_GQL_12_20170818.raw	Raw
	Lumos3_GQL_13_20170818.raw	Raw

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Publications

Mycobacterium tuberculosis ESX-1-secreted substrate protein EspC promotes mycobacterial survival through endoplasmic reticulum stress-mediated apoptosis.

Guo Qinglong Q Bi Jing J Wang Honghai H Zhang Xuelian X

Emerging microbes & infections 20211201 1

EsxA, secreted by the ESAT-6 secretion system 1 (ESX-1) secretion system, is considered the major Mycobacterium tuberculosis (Mtb) virulence determinant. However, the roles of the individual ESX-1 substrates, such as EspC, remain unclear due to their interdependency for secretion with EsxA. Here, we validated that EspC triggered ER stress-mediated apoptosis in macrophages. The EspC-mediated ER stress was involved in pro-inflammatory cytokines generation, intracellular Ca2+</su ...[more]

PMID: 33290182

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