Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Cell Culture
SUBMITTER: Leslie MULLER
LAB HEAD: Christine CARAPITO
PROVIDER: PXD013696 | Pride | 2021-09-08
REPOSITORIES: Pride
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Schleiss Cedric C Carapito Raphael R Fornecker Luc-Matthieu LM Muller Leslie L Paul Nicodème N Tahar Ouria O Pichot Angelique A Tavian Manuela M Nicolae Alina A Miguet Laurent L Mauvieux Laurent L Herbrecht Raoul R Cianferani Sarah S Freund Jean-Noel JN Carapito Christine C Maumy-Bertrand Myriam M Bahram Seiamak S Bertrand Frederic F Vallat Laurent L
Leukemia 20210408 5
B-cell receptor (BCR) signaling is crucial for the pathophysiology of most mature B-cell lymphomas/leukemias and has emerged as a therapeutic target whose effectiveness remains limited by the occurrence of mutations. Therefore, deciphering the cellular program activated downstream this pathway has become of paramount importance for the development of innovative therapies. Using an original ex vivo model of BCR-induced proliferation of chronic lymphocytic leukemia cells, we generated 108 temporal ...[more]