Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Armel Nicolas
LAB HEAD: Michael Antoniou
PROVIDER: PXD013744 | Pride | 2019-08-29
REPOSITORIES: Pride
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DCB_3787.raw | Raw | |||
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Antoniou Michael N MN Nicolas Armel A Mesnage Robin R Biserni Martina M Rao Francesco V FV Martin Cristina Vazquez CV
BMC research notes 20190808 1
<h4>Objectives</h4>Glyphosate (N-phosphonomethyl glycine) and its commercial herbicide formulations have been shown to exert toxicity via various mechanisms. It has been asserted that glyphosate substitutes for glycine in polypeptide chains leading to protein misfolding and toxicity. However, as no direct evidence exists for glycine to glyphosate substitution in proteins, including in mammalian organisms, we tested this claim by conducting a proteomics analysis of MDA-MB-231 human breast cancer ...[more]