Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Kasper Rand
LAB HEAD: Kasper D. Rand
PROVIDER: PXD013750 | Pride | 2019-05-15
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
DatasetNaK5-HT.zip | Other | |||
DatasetNaS-citalopram.zip | Other | |||
DatasetNacocaineibogaine.zip | Other | |||
MSMS.zip | Other | |||
OverviewofrawdatafilesforMolleretal2019NatComm.xlsx | Xlsx |
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Nature communications 20190411 1
The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatment of depression, anxiety and post-traumatic stress. Here, we apply hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics of human SERT in the absence and presence of known ...[more]