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Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum

ABSTRACT: Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioactive compounds. By the combination of affinity enrichment and high-resolution LC-MS/MS analysis, large-scale lysine succinylome analysis was performed. Altogether, 742 lysine succinylation sites in 382 protein groups were identified. Bioinformatics analysis revealed that the modified proteins were involved in multiple cellular functions and participated in a wide variety of biological processes such as carbon metabolism and biosynthesis of secondary metabolites.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Ganoderma Lucidum

SUBMITTER: Guangyuan Wang

LAB HEAD: Lizhong Guo

PROVIDER: PXD013954 | Pride | 2019-07-25

REPOSITORIES: Pride

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Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum.

Wang Guangyuan G Xu Lili L Yu Hao H Gao Jie J Guo Lizhong L

BMC genomics 20190716 1

<h4>Background</h4>Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioactive compounds. However, the regulation of these bioactive compounds biosynthesis is still unclear. Lysine succinylation is a critical post-translational modification and has many important functions in all aspects of eukaryotic and prokaryotic cells. Although it has been studied for a long time, its function is still unclear in G. lucidum. In this study, a global i ...[more]

PMID: 31311503

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