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HDA714 is a versatile protein lysine deacetylase regulating metabolic and translational activities

ABSTRACT: The rice genome encodes 18 HDACs from the three different families. The RPD3 family comprises 14 genes, the HDT and the Sir families contain each 2 genes. Previous studies showed that rice RPD3 members are involved in various developmental processes. In this work, we used quantitative proteomics to investigate the acetylomes regulated by rice rpd3 family HDAC proteins in seedlings. Our results establish an unprecedentedly comprehensive protein acetylome in plants and reveal that HDA714 is a major deacetylase targeting a large number of Kac sites on hundreds of proteins of diverse function. We show that HDA714-dependent deacetylation is required for glycolytic activity, ribosome translational function, and plant growth and development. Our data uncovers novel regulators of protein Kac homeostasis in plants and extends the role of protein Kac in gene expression to translational regulation.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Oryza Sativa (rice)

TISSUE(S): Seedling

SUBMITTER: qiutao xu

LAB HEAD: zhou dao xiu

PROVIDER: PXD014063 | Pride | 2021-03-24

REPOSITORIES: Pride

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	Z8037TPAcR2_rep1_1.raw	Raw
	Z8037TPAcR2_rep1_2.raw	Raw
	Z8037TPAcR2_rep1_3.raw	Raw
	Z8037TPAcR2_rep1_4.raw	Raw
	Z8037TPAcR2_rep1_5.raw	Raw

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