Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Bone Marrow, Macrophage
DISEASE(S): Multiple Sclerosis,Amyotrophic Lateral Sclerosis,Alzheimer's Disease
SUBMITTER: Janica Wiederstein
LAB HEAD: Manolis Pasparakis
PROVIDER: PXD014097 | Pride | 2020-03-23
REPOSITORIES: Pride
Items per page: 1 - 5 of 14 |
Nature communications 20200408 1
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases. RIPK1 kinase activity induces apoptosis and necroptosis, however the mechanisms and phosphorylation events regulating RIPK1-dependent cell death signaling remain poorly understood. Here we show that RIPK1 autophosphorylation at serine 166 plays a critical role for the activatio ...[more]