Proteomics

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Interactions between host and gut microbiota following dietary interventions


ABSTRACT: Increasing the consumption of dietary fibre has been proposed to alleviate the progression of non-communicable diseases such as obesity, type 2 diabetes and cardiovascular disease, yet the effect of dietary fibre on host physiology remains unclear. In this study, we performed a multiple diet feeding study in C57BL/6J mice to compare high fat and high fat modified with dietary fibre diets on host physiology and gut homeostasis by combining proteomic, metagenomic, metabolomic and glycomic techniques with correlation network analysis. We observed significant changes in physiology, liver proteome, gut microbiota and SCFA production in response to high fat diet. Dietary fibre modification did not reverse these changes but was associated with specific changes in the gut microbiota, liver proteome, SCFA production and colonic mucin glycosylation. Furthermore, correlation network analysis identified gut bacterial-glycan associations.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Daniel BUCIO NOBLE  

LAB HEAD: Mark Molloy

PROVIDER: PXD014132 | Pride | 2021-09-08

REPOSITORIES: Pride

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Action DRS
BF1-2.wiff Wiff
BF1-2.wiff.scan Wiff
BF2-1.wiff Wiff
BF2-1.wiff.scan Wiff
BF3-2.wiff Wiff
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Publications

Changes in dietary fiber intake in mice reveal associations between colonic mucin <i>O</i>-glycosylation and specific gut bacteria.

Gamage Hasinika K A H HKAH   Chong Raymond W W RWW   Bucio-Noble Daniel D   Kautto Liisa L   Hardikar Anandwardhan A AA   Ball Malcolm S MS   Molloy Mark P MP   Packer Nicolle H NH   Paulsen Ian T IT  

Gut microbes 20201101 1


The colonic mucus layer, comprised of highly <i>O-</i>glycosylated mucins, is vital to mediating host-gut microbiota interactions, yet the impact of dietary changes on colonic mucin <i>O-</i>glycosylation and its associations with the gut microbiota remains unexplored. Here, we used an array of omics techniques including glycomics to examine the effect of dietary fiber consumption on the gut microbiota, colonic mucin <i>O-</i>glycosylation and host physiology of high-fat diet-fed C57BL/6J mice.  ...[more]

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