QUANTITATIVE SUBCELLULAR PROTEOMICS OF THE ORBITOFRONTAL CORTEX OF SCHIZOPHRENIA PATIENTS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Schizophrenia
SUBMITTER: 
Proteomics Unit
LAB HEAD: Fabio Nogueira
PROVIDER: PXD014350 | Pride | 2019-10-07
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| NIST_human_IT_2012-05-30_7AA.splib | Other | |||
| SRM_analysis.sky | Other | |||
| SRM_analysis.sky.view | Other | |||
| SRM_analysis.skyd | Other | |||
| TQ_1895_NUC46_1.raw | Raw |
Items per page: 5 1 - 5 of 41 |
Publications
Quantitative Subcellular Proteomics of the Orbitofrontal Cortex of Schizophrenia Patients.
Velásquez Erika E Martins-de-Souza Daniel D Velásquez Ingrid I Carneiro Gabriel Reis Alves GRA Schmitt Andrea A Falkai Peter P Domont Gilberto B GB Nogueira Fabio C S FCS
Journal of proteome research 20191028 12
Schizophrenia is a chronic disease characterized by the impairment of mental functions with a marked social dysfunction. A quantitative proteomic approach using iTRAQ labeling and SRM, applied to the characterization of mitochondria (MIT), crude nuclear fraction (NUC), and cytoplasm (CYT), can allow the observation of dynamic changes in cell compartments providing valuable insights concerning schizophrenia physiopathology. Mass spectrometry analyses of the orbitofrontal cortex from 12 schizophre ...[more]
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L., A resource for discovering specific and universal biomarkers for distributed stem cells. PLoS ONE 6(7): e22077. doi:10.1371/journal.pone.0022077 (2011). 2. J. L. Sherley, P. B. Stadler, D. R. Johnson, Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics. Proc. Natl. Acad. Sci. USA 92, 136-140 (1995). 3. Y. Liu, S. A. Bohn, J. L. Sherley, Inosine-5’-monophosphate dehydrogenase is a rate-limiting factor for p53-dependent growth regulation. Mol. Biol. Cell 9, 15-28 (1998). 4. L. Rambhatla et al., Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics. J. Biomed. Biotech. 1, 28-37 (2001). 5. L. Rambhatla, S. Ram-Mohan, J. J. Cheng, J. L. Sherley, Immortal DNA strand co-segregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells. Cancer Research 65, 3155-3161 (2005). 6. Y. Liu et al., Comparison of bax, waf1, and IMP dehydrogenase regulation in response to wild-type p53 expression under normal growth conditions. J. Cell Physiol. 177, 364-376 (1998). 7. M. Noh, thesis, Massachusetts Institute of Technology (2006). 8. T. S. Tanaka et al., Genome-wide expression pr
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