Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, Myeloid Cell
DISEASE(S): Acute Leukemia
SUBMITTER: Samantha Swenson
LAB HEAD: Shannon Mychel Buckley
PROVIDER: PXD014387 | Pride | 2019-11-27
REPOSITORIES: pride
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Cancers 20191103 11
The hematopoietic system is maintained throughout life by stem cells that are capable of differentiating into all hematopoietic lineages. An intimate balance between self-renewal, differentiation, and quiescence is required to maintain hematopoiesis and disruption of this balance can result in malignant transformation. <i>FBXO9</i>, the substrate recognition component from the SCF E3 ubiquitin ligase family, is downregulated in patients with acute myeloid leukemia (AML) compared to healthy bone ...[more]