Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Hematopoietic Cell
DISEASE(S): Noonan Syndrome
SUBMITTER: Bethany Geary
LAB HEAD: Tony Whetton
PROVIDER: PXD014708 | Pride | 2019-10-30
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
2017_05_16_B_001_B.wiff | Wiff | |||
2017_05_16_B_001_B.wiff.scan | Wiff | |||
2017_05_16_B_002.wiff | Wiff | |||
2017_05_16_B_002.wiff.scan | Wiff | |||
2017_05_16_B_003.wiff | Wiff |
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Journal of proteome research 20191112 1
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of early childhood with a poor survival rate, thus there is a requirement for improved treatment strategies. Induced pluripotent stem cells offer the ability to model disease and develop new treatment strategies. JMML is frequently associated with mutations in <i>PTPN</i>11. Children with Noonan syndrome, a development disorder, have an increased incidence of JMML associated with specific germline mutations in < ...[more]