In utero and lactational TCDD exacerbates the effects of hormone treatment in a model of lower urinary tract dysfunction
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Prostate Gland
SUBMITTER: 
Samuel Thomas
LAB HEAD: Lingjun Li
PROVIDER: PXD014752 | Pride | 2020-03-30
REPOSITORIES: Pride
Dataset's files
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Publications
<i>In utero</i> and lactational 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) exposure exacerbates urinary dysfunction in hormone-treated C57BL/6J mice through a non-malignant mechanism involving proteomic changes in the prostate that differ from those elicited by testosterone and estradiol.
Turco Anne E AE Thomas Samuel S Crawford LaTasha K LK Tang Weiping W Peterson Richard E RE Li Lingjun L Ricke William A WA Vezina Chad M CM
American journal of clinical and experimental urology 20200225 1
A recent study directed new focus on the fetal and neonatal environment as a risk factor for urinary dysfunction in aging males. Male mice were exposed <i>in utero</i> and via lactation (IUL) to the persistent environmental contaminant 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) and then administered slow-release, subcutaneous implants of testosterone and estradiol (T+E2) as adults to mimic the hormonal environment of aging men. IUL TCDD exposure worsened T+E2-induced voiding dysfunction. ...[more]
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