Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Hela Cell
SUBMITTER: Boris Simonetti
LAB HEAD: Pete Cullen
PROVIDER: PXD014927 | Pride | 2021-05-28
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Interactome9PlexTMT_Grouped_PS.msf | Msf | |||
Interactome9PlexTMT_IndividualSamples_PS.msf | Msf | |||
InteractomeBlankPreRpt.raw | Raw | |||
InteractomeBlankPreRun.msf | Msf | |||
InteractomeBlankPreRun.raw | Raw |
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Nature cell biology 20191001 10
Protein trafficking requires coat complexes that couple recognition of sorting motifs in transmembrane cargoes with biogenesis of transport carriers. The mechanisms of cargo transport through the endosomal network are poorly understood. Here, we identify a sorting motif for endosomal recycling of cargoes, including the cation-independent mannose-6-phosphate receptor and semaphorin 4C, by the membrane tubulating BAR domain-containing sorting nexins SNX5 and SNX6. Crystal structures establish that ...[more]