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Extracellular matrix analysis of human keloid scars

ABSTRACT: Fibrosis is vaguely described as connective tissue deposition that can be excessive in pathological conditions. This suggests a quantitative spectrum of fibrosis wherein there can be more or less extracellular matrix (ECM), which in the context of a repairing skin wound could reflect the range from normal scar to keloid. This depiction, however, does not encompass the potential qualitative differences between normal and pathological scars. In keloids, the markedly different physical (hard and dense) and histological (hyalinization) characteristics compared to normal scars indicate an altered and inappropriate matrix, rather than simply too much. With this quantitative discovery-based proteomics we provide a thorough molecular description of keloid lesions relative to normal scars, which is an essential step towards our understanding of this problem.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin

DISEASE(S): Wounds And Injuries

SUBMITTER: Tanya Shaw

LAB HEAD: Tanya Shaw

PROVIDER: PXD015057 | Pride | 2019-12-03

REPOSITORIES: Pride

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			Action	DRS
	Tanya_Skin_GuHCl_01_160604130153.mzid.gz	Mzid
	Tanya_Skin_GuHCl_01_160604130153.mzid_Tanya_Skin_GuHCl_01_160604130153.MGF	Mzid
	Tanya_Skin_GuHCl_01_160604130153.mzid_Tanya_Skin_GuHCl_01_160604130153.pride.mgf.gz	Mzid
	Tanya_Skin_GuHCl_01_160604130153.raw	Raw
	Tanya_Skin_GuHCl_02_160604150442.mzid.gz	Mzid

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