Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Vermiform Appendix, Prefrontal Cortex
DISEASE(S): Parkinson's Disease
SUBMITTER: Juozas Gordevicius
LAB HEAD: Viviane Labrie
PROVIDER: PXD015079 | Pride | 2020-02-18
REPOSITORIES: pride
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Genome biology 20200309 1
<h4>Background</h4>Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson's disease (PD), but its molecular determinants are unknown. Here, we identify divergent epigenetic patterns involved in hemispheric asymmetry by profiling DNA methylation in isolated prefrontal cortex neurons from control and PD brain hemispheres. DNA methylation is fine-mapped at enhancers and promoters, genome-wide, by targeted bisulfite sequ ...[more]