Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Fan Liu
LAB HEAD: Fan Liu
PROVIDER: PXD015160 | Pride | 2020-12-03
REPOSITORIES: Pride
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Gonzalez-Lozano M A MA Koopmans F F Sullivan P F PF Protze J J Krause G G Verhage M M Li K W KW Liu F F Smit A B AB
Science advances 20200219 8
Synaptic transmission is the predominant form of communication in the brain. It requires functionally specialized molecular machineries constituted by thousands of interacting synaptic proteins. Here, we made use of recent advances in cross-linking mass spectrometry (XL-MS) in combination with biochemical and computational approaches to reveal the architecture and assembly of synaptic protein complexes from mouse brain hippocampus and cerebellum. We obtained 11,999 unique lysine-lysine cross-lin ...[more]