Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE134645
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryo, Early Embryonic Cell
SUBMITTER: Joel Chick
LAB HEAD: Peter Sicinski
PROVIDER: PXD015173 | Pride | 2020-10-05
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
114457_w24623_CDK1_wt_old.pep.xml | Pepxml | |||
114458_w24625_CDK1_AS_old.pep.xml | Pepxml | |||
124656_v16783_cdk1_wt_071213.pep.xml | Pepxml | |||
124657_v16785_cdk1_as_071213.pep.xml | Pepxml | |||
144797_f02267_KI_AS_inh_phos_01.pep.xml | Pepxml |
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Molecular cell 20200401 3
The cyclin-dependent kinase 1 (Cdk1) drives cell division. To uncover additional functions of Cdk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place of wild-type Cdk1. In our study, we focused on embryonic stem cells (ESCs), because this cell type displays particularly high Cdk1 activity. We found that in ESCs, a large fraction of Cdk1 substrates is localized on chromatin. Cdk1 phosphorylates many proteins involved in epigenetic regulation, including writers and ...[more]