Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Whole Body
SUBMITTER: David Meyer
LAB HEAD: Univ.-Prof. Dr. Björn Schumacher
PROVIDER: PXD015354 | Pride | 2020-10-13
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 55 |
Wang Siyao S Meyer David H DH Schumacher Björn B
Nature structural & molecular biology 20201012 12
DNA damage causes cancer, impairs development and accelerates aging. Transcription-blocking lesions and transcription-coupled repair defects lead to developmental failure and premature aging in humans. Following DNA repair, homeostatic processes need to be reestablished to ensure development and maintain tissue functionality. Here, we report that, in Caenorhabditis elegans, removal of the WRAD complex of the MLL/COMPASS H3K4 methyltransferase exacerbates developmental growth retardation and acce ...[more]