Proteomics

Dataset Information

0

Systematic discovery of endogenous ribonucleoprotein complexes - RNA DIF-FRAC Human HEK293T Cells Replicate1


ABSTRACT: The associated files are mass spec data from size exclusion chromatographic separations of Human HEK293T with and without RNAse A treatment.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Kevin Drew  

LAB HEAD: Edward Marcotte

PROVIDER: PXD015406 | Pride | 2019-10-18

REPOSITORIES: Pride

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Publications


RNA-binding proteins (RBPs) play essential roles in biology and are frequently associated with human disease. Although recent studies have systematically identified individual RNA-binding proteins, their higher-order assembly into ribonucleoprotein (RNP) complexes has not been systematically investigated. Here, we describe a proteomics method for systematic identification of RNP complexes in human cells. We identify 1,428 protein complexes that associate with RNA, indicating that more than 20% o  ...[more]

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