Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Caenorhabditis Elegans
TISSUE(S): Whole Body
SUBMITTER: Christian Koehler
LAB HEAD: Bernd Thiede
PROVIDER: PXD015644 | Pride | 2020-01-13
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
RB_160611_Henok_NC1_1.mgf | Mgf | |||
RB_160611_Henok_NC1_1.raw | Raw | |||
RB_160611_Henok_NC1_1_F013373.dat | Other | |||
RB_160611_Henok_NC1_2.mgf | Mgf | |||
RB_160611_Henok_NC1_2.raw | Raw |
Items per page: 1 - 5 of 96 |
Nature communications 20191121 1
Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic deficit can be targeted for therapeutic intervention has not been determined. Here we report impaired mitophagy and depletion of NAD<sup>+</sup>, a fundamental ubiquitous molecule, in WS patient samples ...[more]