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Dog platelets proteome by label-free quantiative LC-MS/MS analysis

ABSTRACT: Proteomic analyses of the proteins secreted from dog platelets using label-free quantitationworkflow.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Blood Platelet

SUBMITTER: Sheng Zhang

LAB HEAD: Sheng Zhang

PROVIDER: PXD015864 | Pride | 2019-10-29

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Signe10390340_Concentrate_Samples_Dog1.mgf	Mgf
	Signe10390340_Concentrate_Samples_Dog1.msf	Msf
	Signe10390340_Pellet_Samples_Dog1.mgf	Mgf
	Signe10390340_Pellet_Samples_Dog1.msf	Msf
	Signe10390340_ReleasateConcentrate_Slice2_Dog1.raw	Raw

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Publications

Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS).

Cremer Signe E SE Catalfamo James L JL Goggs Robert R Seemann Stefan E SE Kristensen Annemarie T AT Brooks Marjory B MB

PloS one 20191113 11

Domestic dogs share the same environment as humans, and they represent a valuable animal model to study naturally-occurring human disease. Platelet proteomics holds promise for the discovery of biomarkers that capture the contribution of platelets to the pathophysiology of many disease states, however, canine platelet proteomic studies are lacking. Our study objectives were to establish a protocol for proteomic identification and quantification of the thrombin-activated canine platelet secretome ...[more]

PMID: 31721811

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