Proteomics

Dataset Information

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A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer


ABSTRACT: HLA ligandome analysis of colorectal adenocarcinoma tissues obtained from liver metastases (mCRC) as well as adjacent non-malignant liver tissues was performed to characterize the natural HLA class I and class II presented ligands on both mCRC and adjacent liver tissue.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver, Epithelial Cell

DISEASE(S): Colon Cancer

SUBMITTER: Lena Mühlenbruch  

LAB HEAD: Hans-Georg Rammensee

PROVIDER: PXD015947 | Pride | 2019-12-11

REPOSITORIES: Pride

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<b>Background:</b> Radiofrequency ablation (RFA) is an established treatment option for malignancies located in the liver. RFA-induced irreversible coagulation necrosis leads to the release of danger signals and cellular content. Hence, RFA may constitute an endogenous <i>in situ</i> tumor vaccination, stimulating innate and adaptive immune responses, including tumor-antigen specific T cells. This may explain a phenomenon termed abscopal effect, namely tumor regression in untreated lesions evide  ...[more]

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