Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap XL
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Liver, Epithelial Cell
DISEASE(S): Colon Cancer
SUBMITTER: Lena Mühlenbruch
LAB HEAD: Hans-Georg Rammensee
PROVIDER: PXD015947 | Pride | 2019-12-11
REPOSITORIES: Pride
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Löffler Markus W MW Nussbaum Bianca B Jäger Günter G Jurmeister Philipp S PS Budczies Jan J Pereira Philippe L PL Clasen Stephan S Kowalewski Daniel J DJ Mühlenbruch Lena L Königsrainer Ingmar I Beckert Stefan S Ladurner Ruth R Wagner Silvia S Bullinger Florian F Gross Thorben H TH Schroeder Christopher C Sipos Bence B Königsrainer Alfred A Stevanović Stefan S Denkert Carsten C Rammensee Hans-Georg HG Gouttefangeas Cécile C Haen Sebastian P SP
Frontiers in immunology 20191119
<b>Background:</b> Radiofrequency ablation (RFA) is an established treatment option for malignancies located in the liver. RFA-induced irreversible coagulation necrosis leads to the release of danger signals and cellular content. Hence, RFA may constitute an endogenous <i>in situ</i> tumor vaccination, stimulating innate and adaptive immune responses, including tumor-antigen specific T cells. This may explain a phenomenon termed abscopal effect, namely tumor regression in untreated lesions evide ...[more]