Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Oligodendrocyte
DISEASE(S): Multiple Sclerosis
SUBMITTER: Hannes Drexler
LAB HEAD: Hannes C. A. Drexler
PROVIDER: PXD016043 | Pride | 2020-09-04
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
andromeda.7z | Other | |||
exp1048.7z | Other | |||
txt.7z | Other |
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Starost Laura L Lindner Maren M Herold Martin M Xu Yu Kang T YKT Drexler Hannes C A HCA Heß Katharina K Ehrlich Marc M Ottoboni Linda L Ruffini Francesca F Stehling Martin M Röpke Albrecht A Thomas Christian C Schöler Hans R HR Antel Jack J Winkler Jürgen J Martino Gianvito G Klotz Luisa L Kuhlmann Tanja T
Acta neuropathologica 20200907 5
Multiple sclerosis (MS) is the most frequent demyelinating disease in young adults and despite significant advances in immunotherapy, disease progression still cannot be prevented. Promotion of remyelination, an endogenous repair mechanism resulting in the formation of new myelin sheaths around demyelinated axons, represents a promising new treatment approach. However, remyelination frequently fails in MS lesions, which can in part be attributed to impaired differentiation of oligodendroglial pr ...[more]