Proteomics

Dataset Information

0

Proteomics exploration of the human RPL3 interactome


ABSTRACT: Exploring the interactome of human RPL3 by MS-based proteomics.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Magnus Jakobsson  

LAB HEAD: Jesper V. Olsen

PROVIDER: PXD016055 | Pride | 2021-09-08

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20170320_QE3_nLC11_MJ_GFP_Rep1.raw Raw
20170320_QE3_nLC11_MJ_GFP_Rep2.raw Raw
20170320_QE3_nLC11_MJ_GFP_Rep3.raw Raw
20170320_QE3_nLC11_MJ_GFP_Rep4.raw Raw
20170320_QE3_nLC11_MJ_GFP_Rep5.raw Raw
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Publications

Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function.

Małecki Jędrzej M JM   Odonohue Marie-Francoise MF   Kim Yeji Y   Jakobsson Magnus E ME   Gessa Luca L   Pinto Rita R   Wu Jie J   Davydova Erna E   Moen Anders A   Olsen Jesper V JV   Thiede Bernd B   Gleizes Pierre-Emmanuel PE   Leidel Sebastian A SA   Falnes Pål Ø PØ  

Nucleic acids research 20210401 6


Protein methylation occurs primarily on lysine and arginine, but also on some other residues, such as histidine. METTL18 is the last uncharacterized member of a group of human methyltransferases (MTases) that mainly exert lysine methylation, and here we set out to elucidate its function. We found METTL18 to be a nuclear protein that contains a functional nuclear localization signal and accumulates in nucleoli. Recombinant METTL18 methylated a single protein in nuclear extracts and in isolated ri  ...[more]

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