Dataset Information
293T Flag-Aurora-A Co-IP LC-MSMS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Aoxing Cheng
LAB HEAD: zhenye yang
PROVIDER: PXD016110 | Pride | 2019-11-21
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Flag-Auror-A-1.raw | Raw | |||
| Flag-Auror-A-1.xml | Xml | |||
| Flag-Auror-A-2.raw | Raw | |||
| Flag-Auror-A-2.xml | Xml | |||
| Flag-Auror-A-3.raw | Raw |
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Publications
Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect.
Nature communications 20191205 1
Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether Aurora-A is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing p ...[more]
