Dataset Information

Protemics of human cell during HHV-6A reactivation

ABSTRACT: HHV-6A is a human herpesvirus that integrates into human sub telomeric regions to acquire latency. This latent virus frequently reactivates causing numerous diseases. The project was aimed to understand changes in host cell prteomics upon virus reactivation, which might helpin understanding the pathophysiology of virus reactivation.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Bhupesh Kumar Prusty

LAB HEAD: Bhupesh Kumar Prusty

PROVIDER: PXD016211 | Pride | 2020-04-07

REPOSITORIES: Pride

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			Action	DRS
	2018-10-19_Fusion_15892.raw	Raw
	2018-10-19_Fusion_15893.raw	Raw
	2018-10-19_Fusion_15894.raw	Raw
	2018-10-19_Fusion_15895.raw	Raw
	2018-10-19_Fusion_15896.raw	Raw

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Publications

Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Schreiner Philipp P Harrer Thomas T Scheibenbogen Carmen C Lamer Stephanie S Schlosser Andreas A Naviaux Robert K RK Prusty Bhupesh K BK

ImmunoHorizons 20200423 4

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifactorial disorder with many possible triggers. Human herpesvirus (HHV)-6 and HHV-7 are two infectious triggers for which evidence has been growing. To understand possible causative role of HHV-6 in ME/CFS, metabolic and antiviral phenotypes of U2-OS cells were studied with and without chromosomally integrated HHV-6 and with or without virus reactivation using the histone deacetylase inhibitor trichostatin-A. Proteomic analysi ...[more]

PMID: 32327453

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