Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Early Embryonic Cell
SUBMITTER: Jia Zhou
LAB HEAD: Alan D'Andrea
PROVIDER: PXD016256 | Pride | 2020-01-20
REPOSITORIES: pride
Action | DRS | |||
---|---|---|---|---|
IP-GFP-NEIL3-UT52819_76781.mzid | Mzid | |||
IP-GFP-NEIL3-UT76781.mgf | Mgf | |||
IP-GFP-NEIL3-UT76781.raw | Raw | |||
IP_GFP_NEIL3_PUVA1h53307_77137.mzid | Mzid | |||
IP_GFP_NEIL3_PUVA1h77137.mgf | Mgf |
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Nucleic acids research 20200401 6
The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions from DNA. Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in Xenopus extracts, how NEIL3 participants in ICL repair in human cells and its corporation with the canonical Fanconi anemia (FA)/BRCA pathway remain unclear. Here we show that the NEIL3 and the FA/BRCA pathways are non-epistatic in psoralen-ICL repair. The NEIL3 pathway is the major pathway for repairing psoralen-ICL, and the ...[more]