Proteomics

Dataset Information

0

Hippocampus proteome Mus musculus


ABSTRACT: To describe the protein profile in hippocampus, colon and ileum tissue’ changing after the old faeces transplants, we adopted a quantitative label free proteomics approach.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hippocampus

SUBMITTER: Alfonsina D'Amato  

LAB HEAD: Alfonsina D'Amato

PROVIDER: PXD016432 | Pride | 2021-09-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
17_02_23_A10_1.raw Raw
17_02_23_A10_2.raw Raw
17_02_23_A10_3.raw Raw
17_02_23_A11_1.raw Raw
17_02_23_A11_2.raw Raw
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Publications

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients.

D'Amato Alfonsina A   Di Cesare Mannelli Lorenzo L   Lucarini Elena E   Man Angela L AL   Le Gall Gwenaelle G   Branca Jacopo J V JJV   Ghelardini Carla C   Amedei Amedeo A   Bertelli Eugenio E   Regoli Mari M   Pacini Alessandra A   Luciani Giulia G   Gallina Pasquale P   Altera Annalisa A   Narbad Arjan A   Gulisano Massimo M   Hoyles Lesley L   Vauzour David D   Nicoletti Claudio C  

Microbiome 20201001 1


<h4>Background</h4>The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems; however, evidence of their direct impact on cognitive functions is still lacking. We tested whether faecal microbiota transplant (FMT) from aged donor mice into young adult recipients altered the hippocampus, an area of the central nervous system (CNS) known to be affected by the ageing process and related  ...[more]

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