Proteomics

Dataset Information

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MEK and PI3K resistant proteome of pancreatic cancer cells


ABSTRACT: MEK and PI3K inhibition on pancreatic cancer cells has demonstrated the existence of intrinsic resistance. Therefore, a comprehensive proteome profiling is needed to understand the associated molecular phenotype. PANC-1 and MIA PaCa-2 cancer cells were studied by label-free data-independent acquisition (SWATH) mass spectrometry with extensive peptide fractionation to quantitate and reveal differential expression of several proteins between resistant and sensitive cells. Proteomic differences cover a broad scope of molecular processes and putative candidate proteins for drug response.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Pancreas

DISEASE(S): Pancreas Adenocarcinoma

SUBMITTER: Juan Francisco Martinez-Aguilar  

LAB HEAD: Juan Francisco

PROVIDER: PXD016493 | Pride | 2025-03-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
190601_Micro_MiaPaCa_SWATH_1.1.wiff Wiff
190601_Micro_MiaPaCa_SWATH_1.1.wiff.scan Wiff
190601_Micro_MiaPaCa_SWATH_2.wiff Wiff
190601_Micro_MiaPaCa_SWATH_2.wiff.scan Wiff
190601_Micro_MiaPaCa_SWATH_3.wiff Wiff
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