MEK and PI3K resistant proteome of pancreatic cancer cells
Ontology highlight
ABSTRACT: MEK and PI3K inhibition on pancreatic cancer cells has demonstrated the existence of intrinsic resistance. Therefore, a comprehensive proteome profiling is needed to understand the associated molecular phenotype. PANC-1 and MIA PaCa-2 cancer cells were studied by label-free data-independent acquisition (SWATH) mass spectrometry with extensive peptide fractionation to quantitate and reveal differential expression of several proteins between resistant and sensitive cells. Proteomic differences cover a broad scope of molecular processes and putative candidate proteins for drug response.
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Pancreas
DISEASE(S): Pancreas Adenocarcinoma
SUBMITTER:
Juan Francisco Martinez-Aguilar
LAB HEAD: Juan Francisco
PROVIDER: PXD016493 | Pride | 2025-03-10
REPOSITORIES: Pride
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