HHIP-AS1 lncRNA promotes tumorigenicity in human SHH-driven brain tumors
Ontology highlight
ABSTRACT: Long non-coding RNAs (lncRNAs) comprise a diverse class of gene expression regulators with emerging roles in many biological processes including cancer. Here we show that the expression of the lncRNA Hedgehog Interacting Protein Antisense 1 (HHIP-AS1) is a hallmark feature of human SHH-driven tumors. Importantly, loss of HHIP-AS1 leads to reduced tumor growth in SHH-driven tumors in vitro and in vivo. Our results demonstrate the power of cross-entity transcriptome-wide comparisons to identify novel epigenetic–regulatory lncRNA circuitries underlying human cancers.
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Medulloblastoma
SUBMITTER: Nina Overbeck
LAB HEAD: Kai Stühler
PROVIDER: PXD016550 | Pride | 2022-06-01
REPOSITORIES: Pride
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