Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Colon
DISEASE(S): Colon Cancer
SUBMITTER: Laura Demmers
LAB HEAD: Wei Wu
PROVIDER: PXD016582 | Pride | 2020-10-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Ligandome_Raw.7z | Other | |||
MaxQuant_search-output.7z | Other | |||
Patient41-ligandome_non-personalized_intensityquant_not-normalized.msf | Msf | |||
Proteome_Raw.7z | Other |
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Nature communications 20201021 1
Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte antigen (HLA) peptide ligands are promising leads to invoke targeted anti-tumor responses. Here, we investigate the variability in HLA class I peptide presentation between different clonal cells of the same colorectal cancer patient, using an organoid system. While clone-specific differences in HLA peptide presentation ...[more]