Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Pancreas
DISEASE(S): Pancreatitis
SUBMITTER: Zhang guowei
LAB HEAD: Guo-wei Zhang
PROVIDER: PXD016703 | Pride | 2021-09-09
REPOSITORIES: Pride
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Tan Jie-Hui JH Cao Rong-Chang RC Zhou Lei L Zhou Zhi-Tao ZT Chen Huo-Ji HJ Xu Jia J Chen Xue-Mei XM Jin Yang-Chen YC Lin Jia-Yu JY Zeng Jun-Ling JL Li Shu-Ji SJ Luo Min M Hu Guo-Dong GD Yang Xiao-Bing XB Jin Jin J Zhang Guo-Wei GW
Theranostics 20200709 18
<b>Background:</b> There is no curative therapy for severe acute pancreatitis (SAP) due to poor understanding of its molecular mechanisms. Endoplasmic reticulum (ER) stress is involved in SAP and increased expression of ATF6 has been detected in SAP patients. Here, we aimed to investigate the role of ATF6 in a preclinical SAP mouse model and characterize its regulatory mechanism. <b>Methods:</b> Pancreatic tissues of healthy and SAP patients were collected during surgery. Humanized PRSS1 transge ...[more]