Proteomics

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Regulation of lipid homeostasis in treatment-resistant prostate cancer

ABSTRACT: Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we performed a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (ARI). Combined proteomics and metabolomics analyses implicated an acquired metabolic phenotype common in ARI-resistant cells and associated with perturbed glucose and lipid metabolism. To exploit this phenotype, we delineated a subset of proteins consistently associated with ARI resistance.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell Of Prostate

DISEASE(S): Prostate Cancer

SUBMITTER: Sergio Lilla  

LAB HEAD: Sara Rossana Zanivan

PROVIDER: PXD016836 | Pride | 2020-05-26

REPOSITORIES: Pride

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170816_SEL_OT_ARB_R08_020816_LNCAP-ENZ-orga_r01_011.raw Raw
170816_SEL_OT_ARB_R08_020816_LNCAP-ENZ-orga_r02_012.raw Raw
170816_SEL_OT_ARB_R08_020816_LNCAP-ENZ-orga_r03_013.raw Raw
170816_SEL_OT_ARB_R08_020816_LNCAP-ENZ-orga_r04_014.raw Raw
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Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (ARI). Combined proteomics and metabolomics analyses implicate an acquired metabolic phenotype common in ARI-resistant cells and associated with perturbed glucose and lipid metabolis  ...[more]

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