Dataset Information

Stimulation of the atypical chemokine receptor 3 inhibits connexin 43 gap junctional intercellular communication

ABSTRACT: The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in various tumors promotes cell proliferation and invasiveness. The intracellular cellular pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we addressed by characterizing the the interactome of recombinant ACKR3 expressed in HEK293T cells. Among the ACKR3-interacting proteins identified, we focused on the gap junction protein Connexin 43 (Cx43).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Oana Vigy

LAB HEAD: Philippe Marin

PROVIDER: PXD016978 | Pride | 2020-07-07

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	ONCORNET_160125_CXCR7_E_21A.raw	Raw
	ONCORNET_160125_CXCR7_E_22A.raw	Raw
	ONCORNET_160125_CXCR7_E_23A.raw	Raw
	ONCORNET_160125_CXCR7_E_24A.raw	Raw
	ONCORNET_160125_CXCR7_E_25A.raw	Raw

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Publications

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication.

Fumagalli Amos A Heuninck Joyce J Pizzoccaro Anne A Moutin Enora E Koenen Joyce J Séveno Martial M Durroux Thierry T Junier Marie-Pierre MP Schlecht-Louf Géraldine G Bachelerie Francoise F Schütz Dagmar D Stumm Ralf R Smit Martine J MJ Guérineau Nathalie C NC Chaumont-Dubel Séverine S Marin Philippe P

Nature communications 20200925 1

The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we addressed by identifying the interactome of ACKR3. Here, we report that recombinant ACKR3 expressed in HEK293T cells recruits the gap junction protein Connexin 43 (Cx43). Cx43 and ACKR ...[more]

PMID: 32978390

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